Oligonucleotides with anti-MDR-1 gene activity

Details Oligonucleotides with anti-MDR-1 gene activity Oligonucleotides with anti-MDR-1 gene activity

1994-07-18

1999-02-02

Campell, Bruce R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 231, 514 44, 935 8, C07H 2104, A61K 4800

Patent

active

058666990

ABSTRACT:
Disclosed are synthetic oligonucleotides having a nucleotide sequence complementary to at least a portion of the multi-drug resistant-1 gene, or transcripts thereof, which portion encodes a nucleoside binding site. Also disclosed is a pharmaceutical formulation containing such oligonucleotides, and methods of treating multidrug resistant cancer cells, of preventing the expression of P170 in a cell, and of preventing the induction of multidrug resistance in a cancer cell.

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