Process for the direct preparation of N,N-disubstituted derivati

Details Process for the direct preparation of N,N-disubstituted derivati Process for the direct preparation of N,N-disubstituted derivati

1986-04-11

1987-08-18

Hollrah, Glennon H.

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

C07D27308, C07D41306

Patent

active

046878440

ABSTRACT:
A process for the direct preparation of N,N-di-substituted derivatives of 4,13-diaza-18-crown-6 in which the substituents on both nitrogen atoms are identical and derive originally from an amine, by reacting a 1,8-diiodo-3,6-dioxooctane or derivatives thereof in which the substituents are located on positions 1, 2, 4, 5, 7 or 8 or combinations thereof, with a molar equivalent of a primary amine in the presence of a base and solvent.

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