Thiazolidinedione derivatives, useful as antidiabetic agents

Details Thiazolidinedione derivatives, useful as antidiabetic agents Thiazolidinedione derivatives, useful as antidiabetic agents

1986-01-17

1987-08-18

Jiles, Henry R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546280, A61K 3144, C07D41704

Patent

active

046877770

ABSTRACT:
Thiazolidinedione derivatives of the formula: ##STR1## and pharmacologically acceptable salts thereof are novel compounds, which exhibit in mammals blood sugar- and lipid-lowering activity, and are of value as a therapeutic agent for treatment of diabetes and hyperlipemia.

REFERENCES:
patent: 4287200 (1981-09-01), Kawamatsu et al.
March, J., Adv. Org. Chem., 2nd ed., pp. 806-807.
Sohda et al., Chem. Pharm. Bull. 30(10) 3563-3573, 3580-3600 (1982).
Fujita et al., Diabetes, vol. 32, 804-810 (1983).
Sohda et al., Chem. Pharm. Bull., 32(6) 2267-2278 (1984).

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