Method of rate immunonephelometric analysis

Details Method of rate immunonephelometric analysis Method of rate immunonephelometric analysis

1978-03-14

1980-05-27

Pendegrass, Verlin R.

Chemistry: physical processes

Physical processes

Crystallization

356 39, 356339, 356341, 356433, 424 12, G01N 3100, G01N 3316, G01N 2100

Patent

active

042048370

ABSTRACT:
A method of determining the need for post-addition of antigen or antibody to an antigen-antibody reaction to ascertain whether the reaction is in an antigen excess or an antibody excess condition. The time rate of change of a nephelometric signal developed from the reaction is monitored to generate a rate signal having a peak value providing a measure of antigen concentration. The post-addition step is performed only if the peak rate value is ambiguous--, i.e. if it indicates one antigen concentration value for a reaction in antigen excess but another value for a reaction in antibody excess. The need for the post-addition step is determined from measured qualities of the rate signal including one or more of (1) the peak rate value, (2) the elapsed time from the start of the reaction to the peak rate, and (3) the product of the peak rate and the elapsed time. When required, the post-addition step may be performed during progress of the antigen-antibody reaction after measurement of the peak rate value.

REFERENCES:
patent: 3725204 (1973-04-01), Marshall
patent: 3730842 (1973-05-01), Wyatt
patent: 3832532 (1974-08-01), Praguin
patent: 3905767 (1975-09-01), Morris
patent: 3967901 (1976-07-01), Rodriguez
patent: 3990851 (1976-11-01), Gross

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