Stable aqueous alfa interferon solution formulations

Details Stable aqueous alfa interferon solution formulations Stable aqueous alfa interferon solution formulations

1998-06-12

1999-08-10

Sayala, Chhaya D.

Drug, bio-affecting and body treating compositions

Lymphokine

Interferon

A61K 3821

Patent

active

059355662

ABSTRACT:
Stable aqueous solution formulations containing alfa-interferon type interferon, e.g., interferon alfa-2a and interferon alfa-2b, a buffer to maintain the pH in the range of 4.5-7.1, polysorbate 80 as a stabilizer, edetate disodium as a chelating agent, sodium chloride as a tonicity agent, and m-cresol as an antimicrobial preservative and which maintain high chemical, physical and biological stability of the alfa-type interferon for an extended storage period of at least 24 months are disclosed.

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Derwent Abstract Database WPI, Derwent AN 84-285358; Derwent Publications, Ltd., London, GB; Abstract of Japanese published patent appln, JP A 59 176216 (Sumitomo Chemical KK).; appln . published Oct. 5 , 1984; Abstract published 46th week of 1984.

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