Insulin preparations containing NaCl

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

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5303892, 53038824, 530303, 530304, A61K 3828, C07K 1462

Patent

active

058665382

ABSTRACT:
Insulin preparations of superior chemical stability, comprising human insulin or an analogue or derivative thereof, glycerol and/or mannitol, and 5 to 100 mM of a halogenide are disclosed.

REFERENCES:
patent: 4439181 (1984-03-01), Blackshear et al.
patent: 5559094 (1996-09-01), Brems et al.
Brange J. and Langkjoer, L. Insulin Structure and stability. In: Stability and characterization of protein and peptide drugs:Case histories, Y.J.Wang, ed., Plenum Press, N.Y., p. 334, Jun. 1993.
Vinita Gupta et al., "Effect of Solvent Additives On the Thermal Stability of Insulin", Centre for Biotechnology, vol. 70., pp. 209-212.

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