Chemistry: analytical and immunological testing – Involving an insoluble carrier for immobilizing immunochemicals – Carrier is inorganic
Patent
1996-03-14
1999-02-02
Chin, Christopher L.
Chemistry: analytical and immunological testing
Involving an insoluble carrier for immobilizing immunochemicals
Carrier is inorganic
422 57, 422 8205, 422 8208, 422 8211, 435 6, 4352871, 4352872, 4352879, 4352887, 435808, 436518, 436524, 436527, 436164, 436165, 436172, 436805, 436807, 385 12, 385129, 385131, G01N 33553
Patent
active
058664335
ABSTRACT:
An optochemical fluorescence sensor with a biorecognitive layer for measuring the concentration of one or more analytes in a sample is provided with at least one island layer which is applied on a sensor substrate. The islands of the island layer are in the form of electrically-conductive material and have a diameter of less than 300 nm, the biorecognitive layer being directly applied on the island layer or bound via a spacer film. In addition, an analyte-specific fluorescent compound is provided which may be added to the sample or is provided in the sensor itself. The biorecognitive layer can bind the analyte to be measured directly or by means of analyte-binding molecules, the originally low quantum yield of the fluorescent compound increasing strongly in the vicinity of the island layer.
REFERENCES:
patent: 4978503 (1990-12-01), Shanks et al.
patent: 5449918 (1995-09-01), Krull et al.
patent: 5527712 (1996-06-01), Sheehy
Aussenegg Franz
Brunner Harald
Leitner Alfred
Pittner Fritz
Schalkhammer Thomas
AVL Medical Instruments AG
Chin Christopher L.
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