Preparation of derivatized 10,10'-substituted-9,9'-biacridine lu

Details Preparation of derivatized 10,10'-substituted-9,9'-biacridine lu Preparation of derivatized 10,10'-substituted-9,9'-biacridine lu

1996-12-16

1999-02-02

Green, Lora M.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

435 71, 435 75, 435 973, 436501, 436518, 436543, 436544, 436164, 436172, 252700, 530300, 530345, 5303913, 530403, 530802, 536 243, 536 2532, G01N 33532

Patent

active

058663355

ABSTRACT:
The synthesis of 10,10'-substituted-9,9'-biacridine molecules and their derivatives is disclosed. These molecules are shown to catalyze the production of light by chemiluminescence in the presence of a signal solution having at a pH from about 10.0 to about 14.0, at a concentration effective for producing a chemiluminescent signal, a chelating agent, a sulfoxide, a reducing sugar, an oxidant or combination of oxidants, an alcohol and aqueous sodium tetraborate. These 10,10'-substituted-9,9'-biacridines are used alone or attached to haptens or macromolecules and are utilized as labels in the preparation of chemiluminescent, homogeneous or heterogeneous assays. They are also used in conjunction with other chemiluminescent label molecules to produce multiple analyte chemiluminescent assays.

REFERENCES:
patent: 4478817 (1984-10-01), Campbell et al.
patent: 5340714 (1994-08-01), Katsilometes
Vlasenko et al., J. Biolum. Chemilum, vol. 4, pp. 164-176 (1989) "An Investigation on teh Catalytic Mechanism of Enhanced Chemiluminescence: Immunochemical Applications of this Reaction".
Papadopoulos et al., J. prakt. Chem., vol. 335, pp. 633-636 (1993) "Synthesis of N,N'-Dialkyl-9-9'-Buacridylidenes and 9,9'-Biacridinium Nitrates Containing Long Alkyl Chains".
Papadopoulos et al., Tetrahedron Letters, vol. 35, No. 8, pp. 1371-1372 (1993) "Synthesis of Novel Protected Hemianimal N-Methoxymethyl-N'-Methyl-9,9'-Biacridylidene from Lucigenin".

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