Methods and materials relating to the functional domains of DNA

Details Methods and materials relating to the functional domains of DNA Methods and materials relating to the functional domains of DNA

1995-06-06

1999-02-02

Jones, W. Gary

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

435 912, 536 231, 536 243, 536 2433, C12Q 168, C19P 1934, C07H 202, C07H 2104

Patent

active

058663258

ABSTRACT:
Disclosed are DNA sequences encoding novel DNA binding proteins implicated in regulation of early stages of cell growth. Illustratively provided are human and mouse origin DNA sequences encoding early growth regulatory ("Egr") proteins which include "zinc finger" regions of the type involved in DNA binding. Also disclosed is a detailed analysis of the structure and function of the early growth regulatory protein, Egr-1, delineating independent and modular activation, repression, DNA-binding, and nuclear localization activities. Also disclosed are immunological methods and materials for detection of Egr proteins and hybridization methods and materials for detection and quantification of Egr protein related nucleic acids.

REFERENCES:
Lau et al. The EMBO Journal, 4: 3145-3151, 1985.

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