Library of glyco-peptides useful for identification of cell adhe

Details Library of glyco-peptides useful for identification of cell adhe Library of glyco-peptides useful for identification of cell adhe

1996-06-10

1998-08-18

Luxton, David

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

Tripeptides, e.g., tripeptide thyroliberin , etc.

530322, 514 18, A61K 3806

Patent

active

057959587

ABSTRACT:
Glycopeptides having the following structure are described: ##STR1## wherein: X.sub.1 is hydrogen, an acetyl group, an acyl group or amino acid; R is .alpha.-L-fucose, .alpha.-D-fucose, .beta.-L-fucose or .beta.-D-fucose, wherein R is O-glucosidically linked to A.sub.1 ; A.sub.1 is serine, threonine, tyrosine, hydroxyproline, asparagine, glutamine, homeoserine and hydroxylysine; A.sub.2 is a glycine, an L-amino acid, a D-amino acid or a modified amino acid; A.sub.3 is L or D aspartic acid, glycine or glutamic acid; and X.sub.2 is a hydroxyl, an amine or an amino acid.

REFERENCES:
patent: 4386026 (1983-05-01), Ponpipon
patent: 4719289 (1988-01-01), Kolar
patent: 4833092 (1989-05-01), Geysen
patent: 5194392 (1993-03-01), Geysen
patent: 5300492 (1994-04-01), Haviv
patent: 5304640 (1994-04-01), Lasky

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