Surgery – Diagnostic testing – Detecting nuclear – electromagnetic – or ultrasonic radiation
Patent
1998-02-27
1999-08-10
Jaworski, Francis J.
Surgery
Diagnostic testing
Detecting nuclear, electromagnetic, or ultrasonic radiation
600506, 600547, A61B 800, A61B 505
Patent
active
059350660
ABSTRACT:
The present invention is a method for assessing capillary permeability to determine vascular lung injury without requiring the injection of radioactive material or requiring the sampling of blood. The method includes measuring impedance and ultrasonic velocity of blood flow through a lung. A hypertonic bolus is injected into the blood flow, and measurements of the blood flow are taken to determine the ultrasonic velocity and the electrical impedance of the blood. These measurements are used to calculate the capillary transport quantity, which is the product of the reflection coefficient for movement of fluid across the capillary barrier and the filtration coefficient. The measured value of the capillary transport quantity can then be compared to a conventional capillary transport quantity for healthy lungs, and one can determine injury by a significant decrease in the measured capillary transport quantity as compared to the standard measurements.
Furthermore, a comparison of the osmotic transient graphs of the plotted indicator curves can serve to acknowledge lung vascular injury. Lung injury can be determined from the measured data when the point of osmotic equilibrium (where the indicator curve crosses the baseline) is significantly delayed as compared to the point of osmotic equilibrium plotted for a healthy lung.
REFERENCES:
patent: 5453576 (1995-06-01), Krivitski
patent: 5595182 (1995-06-01), Krivitski
patent: 5749369 (1998-05-01), Rabinovich et al.
Hunter, M. and Lee, J., Determination of Fluid Extraction and Osmotic Conductance sK in the Lung with Hypertonic NaCl Infusion I, Theory, Microsvasc. Res. 44:307-333, 1992.
Hunter, M. and Lee, J., Determination of Fluid Extraction and Osmotic Conductance sK in the Lung with Hypertonic NaCl Infusion II, Experiments, Microsvasc. Res. 44:307-333, 1992.
Krivitski, N.M., Novel Method to Measure Access Flow During Hemodialysis by Ultrasound Velocity Dilution Technique. ASIO J. 41: M741-M745, 1995.
Jaworski Francis J.
Patterson Mark J.
Vanderbilt University
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