Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1995-06-01
1998-08-18
Low, Christopher S. F.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
435 691, 435 697, 4353201, 435 911, 435 914, 435 9142, 435 915, 4351723, 4352523, 43525233, 935 9, 935 13, 935 29, 935 56, 935 38, 935 60, 935 73, C12P 2102
Patent
active
057957452
ABSTRACT:
Described are methods and means for the construction and microbial expression of quasi-synthetic genes arising from the combination of organic synthesis and enzymatic reverse transcription from messenger RNA sequences incomplete from the standpoint of the desired protein product. Preferred products of expression lack bio-inactivating leader sequences common in eukaryotic expression products but problematic with regard to microbial cleavage to yield bioactive material. Illustrative is a preferred embodiment in which a gene coding for human growth hormone (useful in, e.g., treatment of hypopituitary dwarfism) is constructed and expressed.
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Goeddel David V.
Heyneker Herbert L.
Dreger Walter H.
Genentech Inc.
Low Christopher S. F.
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