Transgenic mice displaying the amyloid-forming pathology of alzh

Details Transgenic mice displaying the amyloid-forming pathology of alzh Transgenic mice displaying the amyloid-forming pathology of alzh

1991-06-17

1995-02-07

Weimar, Elizabeth C.

Multicellular living organisms and unmodified parts thereof and

Nonhuman animal

424 9, 4351423, 536 235, A61K 4900, C12N 1500, C07H 1512

Patent

active

053877420

ABSTRACT:
Cloned recombinant or synthetic DNA sequences related to the pathology of Alzheimer's disease are injected into fertilized mouse eggs. The injected eggs are implanted in pseudo pregnant females and are grown to term to provide transgenic mice whose cells express proteins related to the pathology of Alzheimer's disease. The injected sequences are constructed having promoter sequences connected so as to express the desired protein in brain tissues of the transgenic mouse. The proteins which are preferably ubiquitously expressed include (1) .beta.-amyloid core precursor proteins; and (2) .beta.-amyloid related precursor proteins; and (3) serine protease inhibitor. The transgenic mice provide useful models for studying compounds being tested for their usefulness in treating Alzheimer's disease, and for studying the in vivo interrelationships of these proteins to each other.

REFERENCES:
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