Antigen fraction of Schistosoma mansoni eggs suitable for testin

Details Antigen fraction of Schistosoma mansoni eggs suitable for testin Antigen fraction of Schistosoma mansoni eggs suitable for testin

1976-09-27

1979-06-12

Padgett, Benjamin R.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

Molecular bilayer structure

424 9, 424 88, G01N 3316, A61K 3900, A61K 4300

Patent

active

041580494

ABSTRACT:
Schistosoma mansoni eggs are ground to liberate soluble egg antigens which are fractionated and purified by absorption, gel filtration and/or ion exchange chromatography, and then radioactively labelled with .sup.125 I. A fraction, identified as MSA.sub.1, is specific to the mature egg stage of Schistosoma mansoni and thus can be used to detect the presence of antibody to mature Schistosoma mansoni eggs in a patient's serum even as compared with mature eggs of different Schistosoma (species specific) or of Schistosoma mansoni worms but not mature eggs (stage specific).

REFERENCES:
patent: 3860483 (1975-01-01), Senft
Boros et al., Journal of Experimental Medicine, vol. 132, No. 3, Sep. 1, 1970, pp. 488-507.
Colley, The Journal of Immunology, vol. 115, No. 1, Jul., 1975, pp. 150-156.
Boros, et al., The Journal of Immunology, vol. 114, No. 5, May 1975, pp. 1437-1441.
Pelley, et al., Infection and Immunity, vol. 13, No. 4, Apr. 1976, pp. 1176-1183.

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