Substituted phosphonic acids

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

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546 23, 540450, 540542, 548412, C07F 9564, C07F 9572, C07F 958, C07F 928

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056590350

ABSTRACT:
A method for the production of azacycloalkane-2,2-diphosphonic acids of general formula; ##STR1## where n is a whole number of from 2 to 16, Y is H, an alkyl or alkenyl, a substituted alkyl, or an aryl, such that the group "Y" remains unchanged during the reaction,
by reaction of a lactam with a phosphorus trihalide in the presence of phosphorous acid and/or water, in which the reaction mixture also includes an organic amine and/or or an organic amine salt, said reaction being followed by hydrolysis of the reaction mixture and purification of the reaction product to obtain the diphosphonic acid.
The method is exemplified by the preparation of azacycloheptane-2,2-diphosphonic acid, and azacyclononane-2,2-diphosphonic acid.

REFERENCES:
patent: 3734914 (1973-05-01), Lorenz et al.
patent: 3941772 (1976-03-01), Ploger et al.
patent: 4876339 (1989-10-01), Blum et al.
Chem. Abstracts, vol. 118(9)abst No. 80827t Mar. 1, 1993.
Chem. Abstracts, vol. 112(9)abst. No. 77540-Q Feb. 26, 1990.
Chem. Abstracts, vol. 87(7)abst. No. 53,437-a Aug. 15, 1977.

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