N-aminoalkylfluorenecarboxamides; a new class of dopamine recept

Details N-aminoalkylfluorenecarboxamides; a new class of dopamine recept N-aminoalkylfluorenecarboxamides; a new class of dopamine recept

1995-09-13

1997-08-19

Bernhardt, Emily

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

544294, 544360, 544363, 544376, 546144, 546146, 5462811, 5462841, 546203, 546204, 546265, 546285, C07D29513, C07D21170, A61K 31495, A61K 31445

Patent

active

056590334

ABSTRACT:
Disclosed are compounds of the formula ##STR1## or the pharmaceutically acceptable salts thereof wherein: G represents a group of the formula ##STR2## where R.sub.a and R.sub.b represent hydrogen, or organic or inorganic substituents;
A is an optionally substituted alkylene;
R.sub.1, R.sub.2, R.sub.3, R.sub.4 represent organic or inorganic substituents;
R.sub.5 is hydrogen or lower alkyl;
R.sub.6 and R.sub.7 independently represent hydrogen, lower alkyl; or together form a ring of 5-8 members;
Z is nitrogen or carbon; and
W is optionally substituted aryl or heteroaryl.
Compounds of the present invention demonstrate high affinity and selectivity in binding to the D.sub.3 receptor subtype.

REFERENCES:
patent: 3726870 (1973-04-01), Rey-Bellet et al.
patent: 5395835 (1995-03-01), Glase et al.
Murray et al., (1995), "A Novel Series of Arylpiperazines with High Affinity and Selectivity for the Dopamine D.sub.3 Receptor," Bioorg, Med. Chem. Let., vol. 5, No. 3, pp. 219-222.

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