Bioadhesive-wound healing compositions and methods for preparing

Details Bioadhesive-wound healing compositions and methods for preparing Bioadhesive-wound healing compositions and methods for preparing

1995-05-22

1997-08-19

Criares, Theodore J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

C-o-group doai

514725, 514458, 514904, 514969, 514887, 514886, 514943, 424DIG13, 424445, 424446, 424447, A61K 31045, A61K 3107, A61K 31355, A61L 1500

Patent

active

056589565

ABSTRACT:
The present invention pertains to therapeutic bioadhesive-wound healing compositions useful for treating wounds and increasing the proliferation and resuscitation rate of mammalian cells. The compositions comprise a bioadhesive agent and a therapeutically effective amount of a wound healing composition. In one embodiment the wound healing composition comprises (a) pyruvate; (b) an antioxidant; and (c) a mixture of saturated and unsaturated fatty acids. The therapeutic bioadhesive-wound healing compositions may further comprise medicaments such as antiviral agents, antikeratolytic agents, anti-inflammatory agents, antifungal agents, antibacterial agents, immunostimulating agents, and the like. The bioadhesive-wound healing compositions may be utilized in a wide variety of pharmaceutical products. This invention also relates to methods for preparing and using the bioadhesive-wound healing compositions and the pharmaceutical products in which the compositions may be used.

REFERENCES:
patent: 3887702 (1975-06-01), Baldwin
patent: 3920835 (1975-11-01), Van Scott et al.
patent: 3984566 (1976-10-01), Van Scott et al.
patent: 3988470 (1976-10-01), Van Scott et al.
patent: 4105783 (1978-08-01), Yu et al.
patent: 4158057 (1979-06-01), Stanko
patent: 4170821 (1979-10-01), Booth
patent: 4197316 (1980-04-01), Yu et al.
patent: 4234599 (1980-11-01), Van Scott et al.
patent: 4246261 (1981-01-01), Van Scott et al.
patent: 4284630 (1981-08-01), Yu et al.
patent: 4294852 (1981-10-01), Wildnauer et al.
patent: 4351835 (1982-09-01), Stanko
patent: 4363815 (1982-12-01), Yu et al.
patent: 4415576 (1983-11-01), Stanko
patent: 4416982 (1983-11-01), Tsuda et al.
patent: 4451482 (1984-05-01), Cagen
patent: 4454159 (1984-06-01), Musher
patent: 4496536 (1985-01-01), Moller
patent: 4521375 (1985-06-01), Houlsby
patent: 4533637 (1985-08-01), Yamane
patent: 4548937 (1985-10-01), Stanko
patent: 4615697 (1986-10-01), Robinson
patent: 4645764 (1987-02-01), Stanko
patent: 4663166 (1987-05-01), Veech
patent: 4696917 (1987-09-01), Lindstrom et al.
patent: 4725586 (1988-02-01), Lindstrom et al.
patent: 4734276 (1988-03-01), Ziegler
patent: 4812479 (1989-03-01), Stanko
patent: 4847069 (1989-07-01), Bissett et al.
patent: 4847071 (1989-07-01), Bissett et al.
patent: 4847072 (1989-07-01), Bissett et al.
patent: 4874603 (1989-10-01), Fratzer
patent: 5084482 (1992-01-01), Hirsch et al.
patent: 5296307 (1994-03-01), Martin et al.
Bauer, G., et al, "Reversal of Doxorubicin-Impaired Wound Healing Using Triad Compound," The American Surgeon, vol. 60, No. 6, Jun. 1994, pp. 455-459.
Duchene, D., et al., "Pharmaceutical and Medical Aspects of Bioadhesive Systems from Drug Administration," Drug Development and Industrial Pharmacy, vol. 14, No. 2-3, 1988, pp. 283-318.
Giannelli, S. Jr., et al. (May 1976). Prevention of increased hemoglobin-oxygen affinity in open-heart operations with inosine-phosphate-pyruvate solution. Annals of Thoracic Surgery, vol. 21, No. 5, pp. 386-396.
Freese, E., et al. (1971). Molecular mechanisms of mutations. In Chemical Mutations (A. Hollander, ed.), Plenum Press, New York-London, pp. 46-48.
Marchek, A. C., et al. (Jun. 1977) Increased in vito growth capacity of tracheal epithelium exposed in vivo to 7, 12 dimethylbenz(a)anthracene. Cancer Research, vol. 37, pp. 1811-1921.
Schwartz, C., et al. (May 7, 1979). Antagonism of cyanide intoxication with sodium pyruvate. Toxicology and Applied Pharmacology, vol. 50, pp. 437-441.
Ahmed, A. M. et al. (1979). Effects of ascorbic acid and various keto-acids on the glyoxalase enzyme system in mouse and rat liver. IRCS Medical Science, vol. 7, pp. 505.
Mochizuki, S., et al. (1980). Energy metabolism during reperfusion following ischemia. J. Physiol., Paris, vol. 76, pp. 805-812.
Cohen, M. H., (Spring, 1981). Cure of Advanced L1210 leukemia after correction of abnormal red blood cell deformability. Cancer Chemother, Pharmacol., vol. 5, pp. 175-179.
Regitz, V., et al. (1981). Biochemical mechanism of infarct size reduction by pyruvate. Cardiovascular Res. vol. 15, pp. 652-658.
Wolters, M., et al. (1982). The effect of x irradiation on survival of mammalian cells substituted by poly unsaturated fatty-acids. Radiat. Res., vol. 93 (3), pp. 474-482.
Puschmann, V. M. (1983). Animal experimental examinations of the gastric mucosa and demonstration of the analgetic and antipyretic effect after combined application of acetylsalicylic acid and sodium pyruvate. Arzneim-Forsch/Drug Res. vol. 33 (I), nr. 3, pp. 410-415.
Puschmann, V. M., et al. (1983). Double-blind controlled gastroscopic comparative study on lesions of the gastric mucosa in healthy volunteers after treatment with acetylsalicylic acid or acetylsalicylic acid/sodium pyruvate. Arzneim-Forsch/Drug Res., vol. 33(I) nr. 33, pp. 415-416.
Subramanyam, K. (Sep. 1984). Effects of Preparation-H on wound healing in the rectum of man. Digestive Diseases and Sciences, vol. 29, No. 9, pp. 829-832.
Bunger, R., et al. (1986). Pyruvate attenuation of hypoxia damage in isolated working guinea-pig heart. J. Mol Cell Cardiol, vol. 18, pp. 234-438.
Andrae, U., et al. (1985). Pyruvate and related a-ketoacids protect mammaliancells in culture against hydrogen peroxide-induced cytotoxicity. Toxicology Letters, vol. 28, pp. 93-98.
Cohen, J., et al. (Jun. 1985). Pregnancies following the frozen storage of expanding human blastocycsts. J. of in Vitro Fertilization and Embryo Transfer, vol. 2, No. 2., pp. 59-64.
Davis, D. L. (1985). Culture and storage of pig embryos. J. Reprod. Fert. Suppl., vol. 33, pp. 115-124.
Ogawa, Y., et al. (Sep. 1986). Comparative study of the effects of pyruvate and CG-120 in preventing experimental oxalate urolithiasis in rats. Acta Urol. Jpn., vol. 32, No. 9, pp. 1341-1347.
Shacter, E. (1987). Serum-free medium for growth factor-dependent and independent plasmacytomas and hybridomas. J. of Immunological Methods, vol. 99, pp. 259-270.
Varma, S. D., et al. (1988). Peroxide damage to the eye lens in vitro prevention by pyruvate. Free Rad. Res. Comms., vol. 4, No. 5, pp. 283-290.
O'Donnell-Tormey, J., et al., (Feb. 1967). Secretion of pyruvate, an antioxidant defense of mammalian cells. J. Exp. Med., vol. 165, pp. 500-514.
Sabri, M. I., et al. (1989). Effect of exogenous pyruvate on acrylamide neuropathy in rats. Brain Research, vol. 483, pp. 1-11.
Mentzer, R. M., et al. (Apr. 1988). Effect of pyruvate on regional ventricular function in normal and stunned myocardium. Ann. of Surgery, vol. 209, No. 4, pp. 629-634.
Martin, A., et al. (1990). A resuscitation/selection system for rapid determination of salmonella in foods. J. Assoc Off. Anal. Chem., vol. 74, No. 3, pp. 522-525.
Martin, A., et al. (1990). A resuscitation medium for rapid recovery and isolation of injured Salmonella, Escherichia coli, Staphylococcus aureus, and listeria in food. (unpublished Ph.D. dissertation, Rutgers Univ., N.J.).
Salahudeen, A. K., et al. (1991). Hydrogen peroxide-induced renal injury, a protective role for pyruvate in vitro and in vivo. J. Clin. Invest., vol. 88, pp. 1886-1893.

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