Inhibition of tumor necrosis factor by retinoic acid

Details Inhibition of tumor necrosis factor by retinoic acid Inhibition of tumor necrosis factor by retinoic acid

1994-11-30

1997-08-19

Weddington, Kevin E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Radical -xh acid, or anhydride, acid halide or salt thereof...

514825, 514895, 514903, A61K 31445

Patent

active

056589492

ABSTRACT:
A novel method of inhibiting production of two important mediators of cellular function, tumor necrosis factor and nitric oxide, and treating a pathophysiological state characterized by an undesirable production or level of tumor necrosis factor or nitric acid. The methods of the present invention employ retinoic acid compounds. The most preferred retinoic acid is all-trans-retinoic acid. Also provided is a method of inhibiting tumor necrosis factor receptors using retinoic acid-like compounds.

REFERENCES:
patent: 5434173 (1995-07-01), Chandraratna
Chemical Abstracts 106:194429; Trinchieri et al. (1987).

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