Succinimide and maleimide cytokine inhibitors

Details Succinimide and maleimide cytokine inhibitors Succinimide and maleimide cytokine inhibitors

1995-10-06

1997-08-19

Haley, Jacqueline

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514309, 514339, 514340, 514421, 514425, 546142, 5462771, 5462784, 5462787, 548465, 548479, 548513, 548547, A61K 3140, C07D20948

Patent

active

056589409

ABSTRACT:
Novel succinimides and maleimides are inhibitors of tumor necrosis factor .alpha. and phosphodiesterase and can be used to combat cachexia, endotoxic shock, retrovirus replication, asthma, and inflammatory conditions. A typical embodiment is methyl 3-(3',4',5',6'-tetrahydrophthalimido)-3-(3",4"-dimethoxyphenyl)propionate.

REFERENCES:
Chemical Abstracts, vol. 117, Abstract 117:145301t (1992).

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