Registers – Systems controlled by data bearing records – Time analysis
Patent
1994-08-15
1997-08-19
LeGuyader, John
Registers
Systems controlled by data bearing records
Time analysis
435 6, 435 9131, 4351721, 4351723, 435325, 435 321, 536 231, 536 232, 536 245, 514 44, C12Q 168, C12N 1585, A61K 4800, C07H 2104
Patent
active
056587805
ABSTRACT:
Enzymatic RNA molecules which cleave rel A mRNA.
REFERENCES:
patent: 4987071 (1991-01-01), Cech
patent: 5168053 (1992-12-01), Altman
patent: 5213580 (1993-05-01), Slepian et al.
patent: 5328470 (1994-07-01), Nabel et al.
Ballantyne et al., "Nucleotide sequence of the cDNA for murine intercellular adhesion molecule-1 (ICAM-1)," Nucleic Acids Research 17:5853 (1989).
Barinaga, "Ribozymes: Killing the Messenger," Science 262:1512-1514 (1993).
Cotten, "The in vivo application of ribozymes," TIBTECH 8:174-178 (1990).
Edgington, "Ribozymes: Stop Making Sense," Biotechnology 10:256-262 (1992).
Kita et al., "Sequence and expression of rat ICAM-1," Biochem. Biophys. Acta 1131:108-110 (1992).
Simons et al., "ICAM, an adhesion ligand of LFA-1, is homologous to the neutral cell adhesion molecule NCAM," Nature 331:624-627 (1988).
Akhtar and Juliano, "Cellular Uptake and Intracellular Fate of AntiSense Oligonucleotides," Trends Cell Biol. 2:139-144 (1992).
Alitalo et al., "Aberrant Expression of An Amplified c-myb oncogene in two cell lines from a colon carcinoma," Proc. Natl. Acad. Sci. USA 81:4534-4538 (1984).
Anfossi et al., "An oligomer complementary to c-myb-encoded mRNA inhibits proliferation of human myeloid leukemia cell lines," Proc. Natl. Acad. Sci. USA 86:3379-3383 (1989).
Austin et al., "Intimal Proliferation of Smooth Muscle Cells as an Explanation for Recurrent Coronary Artery Stenosis After Percutaneous Transluminal Coronary Angioplasty," J. Am. Coll. Cardiol. 6:369-375 (1985).
Banskota et al., "Insulin, Insulin-Like Growth Factor I and Platelet-Derived Growth Factor Interact Additively in the Induction of the Protooncogene c-myc and Cellular Proliferation in Cultured Bovine Aortic Smooth Muscle Cells," Molec. Endocrinol., 3:1183-1190 (1989).
Belknap et al., "Transcriptional Regulation in Vascular Cells: Genetically Modified Animals," J. Cell. Biochem. S18A:277 (1994).
Bennett et al., "Cationic Lipids Enhance Cellular Uptake and Activity of Phosphorothioate Antisense Oligonucleotides," Mol. Pharmacology, 41:1023-1033 (1992).
Biotech Abstracts Act. #91-00050 EP 388758 (Sep. 26, 1990).
Biro et al., "Inhibitory Effects of Antisense Oligodeoxynucleotides targeting c-myc mRNA on smooth muscle cell proliferation and migration," Proc. Natl. Acad. Sci. U S A, 90:654-658 (1993).
Blam et al., "Addition of Growth Hormone Secretion Signal to Basic Fibroblast Growth Factors Results in Cell Transformation and Secretion of Aberrant Forms of the Protein," Oncogene 3:129-136 (1988).
Brown et al., "Expression of the c-myb Proto-oncogene in Bovine Vascular Smooth Muscle Cells," J. Biol. Chem. 267:4625-4630 (1992).
Bywater et al., "Expression of Recombinant Platelet-Derived Growth Factor A-Chain and B-Chaim Homodimers in Rat Cells and Human Fibroblastic Reveals Difference in Protein Processing and Autocrine Effects," Mol. Cell Biol. 8:2753-2762 (1988).
Calabretta et al., "Normal and Leukemic Hematopoietic Cells Manifest Differential Sensitivity to Inhibitory Effects of c-myb Antisense Oligodeoxynucleotides: An in vitro study relevant to bone marrow purging," Proc. Natl. Acad. Sci. USA, 88:2351-2355 (1991).
Califf et al., "Restenosis: The Clinical Issues," in Textbook of Interventional Cardiology, E.J. Topol, ed., W. B. Saunders, Philadelphia, pp. 363-394 (1990).
Cameron and Jennings, "Specific Gene Suppression by Engineered Ribozymes in Monkey Cells." Proc. Natl. Acad. Sci. USA 86:9139 (1989).
Chen, "Multitarget-Ribozyme Directed to Cleave at up to Nine Highly Conserved HIV-1 env RNA Regions Inhibits HIV-1 Replication-Potential Effectiveness Against Most Presently Sequenced HIV-1 Isolates," Nucleic Acids Res. 20:4581-4589 (1992).
Chowrira and Burke, "Extensive Phosphorothioate Substitution Yields Highly Active and Nuclease-Resistant Hairpin Ribozymes," Nucleic Acids Res. 20:2835-2840 (1992).
Chuat and Galibert, "Can Ribozymes be Used to Regulate Procaryote Gene Expression?" Biochem. and Biophys. Res. Comm. 162:1025 (1989).
Cleary et al., "Cloning and Structural Analysis of cDNAs For bcl-2 And A Hybrid bcl-2/Immunoglobulin Transcript Resulting From the t(14;18) Translocation," Cell 47:199-28 (1986).
Clowes et al., "Kinetics of Cellular Proliferation After Arterial Injury," Lab Invest. 49:327-333 (1983).
Collins and Olive, "Reaction Conditions and Kinetics of Self-Cleavage of a Ribozyme Derived From Neurospora VS RNA," Biochemistry 32:2795-2799 (1993).
Cotten et al., "High-Efficiency Receptor-Mediated Delivery of Small and Large (48 Kilobase Gene Constructs using the Endosome-Disruption Activity of Defective or Chemically Inactivated Adenovirus Particles," Proc. Natl. Acad. Sci. USA 89:6094-6098 (1992).
Cotten et al., "Transferrin-Polycation-Mediated Introduction of DNA into Human Leukemic Cells: Stimulation by Agents that Affect the Survival of Transfected DNA or Modulate Transferrin Receptor Levels" (Abstract), Proc. Natl. Acad. Sci. USA 87:4033-4037 (1990).
Cotten et al., "Chicken Adenovirus (CELO Virus) Particles Augment Receptor-Mediated DNA Delivery to Mammalian Cells and Yield Exceptional Levels of Stable Transformants," J. Virol. 67:3777-3785 (1993).
Cristiano et al., "Hepatic Gene Therapy: Adenovirus Enhancement of Receptor-Mediated Gene Delivery and Expression in Primary Hepatocytes," Proc. Natl. Acad. Sci. USA 90:2122-2126 (1993).
Curiel et al., "Adenovirus Enhancement of Transferrin-Polylysine-Mediated Gene Delivery," Proc. Natl. Acad. Sci. USA, 88:8850-8854 (1991).
Dropulic et al., "Functional Characterization of a U5 Ribozyme: Intracellular Suppression of Human Immunodeficiency Virus Type I Expression," J Virol. 66:1432-1441 (1992).
Eck et al., Mol. Cell. Biol. 13:6530-6536 (1993).
Ege et al., "Enhancement of DNA-Mediated Gene Transfer by Inhibitors of Autophagic-Lysosomal Function," Exp. Cell Res. 155:9-16 (1984).
Elroy-Stein and Moss, "Cytoplasmic Expression System Bassed on Constitutive Synthesis of Bacteriophage T7 RNA Polymerase in Mammalian Cells," Proc. Natl. Acad. Sci. USA 87:6743-7 1990).
Ferguson et al., "Compensation for Treating Wounds to Inhibit Scar Tissue--Contains Agent Esp. Antibody, Which Selectively Neutralises Fibrotic Growth Factors," WPI Acc#92-3659974/44.
Ferns et al., "Inhibition of Neointimal Smooth Muscle Accumulation After Angioplasty by an Antibody to PDGF," Science 253:1129-1132 (1991).
Gao and Huang, "Cytoplasmic Expression of a Reporter Gene by Co-Delivery of T7 RNA Polymerase and T7 Promoter Sequence with Cationic Liposomes," Nucleic Acids Res. 21:2867-72 (1993).
Garratt et al., "Differential Histopathology of Primary Atherosclerotic and Restenotic Lesions in Coronary Arteries and Saphenous Vein Bypass Grafts: Analysis of Tissue Obtained From 73 Patients by Directional Atherectomy," J. Am. Coll. Cardio. 17:442-428 (1991).
Goldberg et al., "Vascular Smooth Muscle Cell Kinetics: A New Assay for Studying Patterns of Cellular Proliferation in vivo," Science 205:920-922 (1979).
Griffin and Baylin, "Expression of the c-myb Oncogene in Human Small Cell Lung Carcinoma," Cancer Res. 45:272-275 (1985).
Grotendorst et al., "Attachment of Smooth Muscle Cells to Collagen and Their Migration Toward Platelet-Derived Growth Factor," Proc. Natl. Acad. Sci. USA 78:3669-3672 (982).
Guerrier-Takada et al., "The RNA Moiety of Ribonuclease P Is the Catalytic Subunit of the Enzyme," Cell 35:849 (1983).
Hajjar et al., "Tumor Necrosis Factor-Mediated Release of Platelet-Derived Growth Factor From Cultured Endothelial Cells," J. Exp. Med. 166:235-245 (1987).
Hampel et al., "`Hairpin` Catalytic RNA Model: Evidence for Helices and Sequence Requirement for Substrate RNA", Nucleic Acids Research 18:299-304 (1990).
Harris et al., "Receptor-Mediated Gene Transfer to Airway Epithelial Cells in Primary Culture," Am. J. Respir. Cell Mol. Biol., 9:441-447 (1993).
Haseloff and Gerlach, "Simple RNA Enzymes with New and Highly Specific Endoribonuclease Activities," Nature 334:585-591 (1988).
Herschlag, "Implications of Ribozyme Kinetics for Targeting the Cleavage of Specific RNA Molecules in vivo: More Isn't Always Better," Proc. Natl. Acad. Sci. USA 88:6921-5 (1991).
Hertel et al., "Numbe
Draper Kenneth G.
McSwiggen James
Stinchcomb Dan T.
LeGuyader John
Ribozyme Pharmaceuticals Inc.
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