Production of streptococcal m protein immunogens and molecular p

Details Production of streptococcal m protein immunogens and molecular p Production of streptococcal m protein immunogens and molecular p

1984-06-18

1988-11-15

Wiseman, Thomas G.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Enzymatic production of a protein or polypeptide

435 70, 435 91, 435238, 4351723, 435 32, 935 6, 935 27, 935 29, 935 56, 935 72, 530806, C12P 2100, C12N 1500, C12N 500, C12N 700

Patent

active

047849487

ABSTRACT:
Methods and compositions are provided for the cloning and expression of Streptococcus pyogenes M protein genes, and, in particular, types 5, 6 and 24 genes in single-cell host organisms. The streptococcal M protein produced by the recombinant DNA techniques described herein may be formulated for use as immunogens in vaccines to protect against S. pyogenes infections. The gene for the M protein may further be employed as a molecular probe for the accurate identification of streptococci in infected body tissues and fluids.

REFERENCES:
Manjula et al., 1980, "Studies on Group A Streptococcal M-Proteins . . . " J. Immunol., vol. 124, pp. 261-267.
Scott et al., 1983, "Expression of Streptococcal M Protein in E. coli" Science, vol. 221, 758-60.
Ish-Horowicz et al., 1981, "Rapid and Efficient Cosmid Cloning" Nucl. Acids Res., vol. 9, 2989-98.
Scott et al., 1985, "Relationship of M Protein Genes in Group A Streptococci" Proc. Natl. Acad. Sci., vol. 82, 1822-26.
Burdett et al., 1984, "Cloning and Expression of Streptococcal M-Protein in E. coli" (Abstract) Plasmid, vol. 11 (2) 192-3.
Kehoe et al., 1985, "Cloning and Genetic Analysis of Serotype 5M Protein Determinant of Group A Streptococci . . . " Inf. and Imm., vol. 48, 190-97.
Fischetti et al., 1984, "Streptococcal M6 Protein Expressed in E. coli" J. Exp. Med., vol. 159, 1083-95.
Clarke et al., 1979, "Selection of Specific Clones from Colony Banks by Screening . . . " Methods in Enz., vol. 68, 436-442.

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