Antithrombin III preparation

Details Antithrombin III preparation Antithrombin III preparation

1993-09-30

1995-01-31

Wityshyn, Michael G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 12, 422102, 530393, 436 17, 436 18, A61K 3704

Patent

active

053858905

ABSTRACT:
An antithrombin III is described comprising a lyophilized powder of antithrombin III and a polyoxyethylene glycol sorbitan alkyl ester as well as a kit composed of a container wherein a lyophilized powder of antithrombin III is placed and a solvent for the powder, characterized in that a polyoxyethylene glycol sorbitan alkyl ester is added to either or both of the powder and the solvent. The preparation has a high solubility in water by retaining its activity.

REFERENCES:
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patent: 5319072 (1992-01-01), Uemura et al.
"ICI Americas Products for Cosmeticse and Pharmaceuticals", ICI Americas Inc., pp. 24-25 and 28, 1977.
"Tween 80 Information Sheet".
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Krantz et al., Bulletin of School of Medicine, University of Maryland, vol. 36, pp. 48-56, 1951.
Midori Juji K.K., "Antithrombin Agent and Its Preparation", Patent Abstracts of Japan, C Section, vol. 3, No. 114, Sep. 21, 1979, p. 144, C59, No. 54-95715.
H. J. Kolde "Polyethylene Glycol Can Be Validly Omitted From Chromogenic Peptide Substrate Assay For Antithrombin III", Chemical Abstracts, vol. 105, No. 17, Oct. 27, 1986, p. 296, Abstract-No. 148571u.
H. Van Voorthuizen et al., "Improved Assay Conditions For Automated Antithrombin III Determinations With The Chromogenic Substrate S-2238", Chemical Abstracts, vol. 102, No. 13, Apr. 1, 1985, p. 288, Abstract-No. 108558b.

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