Sialic acid derivatives and process therefor

Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives

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536 41, 536 172, 536 185, 536 187, 536 22, 536 552, 536 553, 536115, 536119, 536120, C07G 300, C08B 3700, C07H 1900

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active

049906038

ABSTRACT:
The present invention relates to sialic acid derivatives. According to the present invention, there is provided sialic acid derivatives having the general formula (I): ##STR1## wherein, R.sup.1 represents hydrogen, an acetyl group, a trityl group, ##STR2## (R.sup.5 represents hydrogen or an acetyl group and R.sup.6 represents hydrogen, sodium or a methyl group).
R.sup.2 represents hydrogen or an acetyl group,

REFERENCES:
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patent: 4751290 (1988-06-01), Ogawa et al.
Carbohydrate Research, 128 (1984) C1-C4.
Carbohydrate Research, vol. 110, 1982, pp. 11-18, Elsevier Scientific Publishing Co. Amsterdam, NL; N. Baggett et al.: "Reinvestigation of the Synthesis of 4-methylcoumarin-7-yl 5-acetamido-3, 5-dideoxy-alpha-D-glycero-D-galacto-2, nonulopyranosis-donic Acid, A Fluoro-genic Substrate . . . ".
Tetrahedron Letters, No. 78, 1979, pp. 4637-4640, Pergamon Press, Ltd, GB; U. Dabrowski et al.: ".sup.1 H-NMR Studies at N-acetyl-D-neuraminic Acid Ketosides for the Determination of the Anomeric Configuration II".
Carbohydrate Research, vol. 78, 1980, pp. 190-194, Elsevier Scientific Publishing Co. Amsterdam, NL; V. Eschenfelder et al.: "A New Approach to the Synthesis of 5-N-acetyl-D-neuraminic and Acid Alpha-Ketosides".
Chemical Abstracts, vol. 87, No. 13, Sep. 26, 1977, pp. 651, 652 Abstract No. 102561x Columbus, Ohio, U.S.; H. J. Jennings et al.: "Isolation of 9-O-(alpha-D-N-acetylneuraminyl)-beta-D-B-acetylneuraminic Acid by Partial Acid Hydrolysis, and Its Characterization by Carbon-13 NMR" & Carbohydr. Res. . . . .

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