Preparation of 7-acylamido-7-methoxy-3-substituted methyl-3(or 2

Details Preparation of 7-acylamido-7-methoxy-3-substituted methyl-3(or 2 Preparation of 7-acylamido-7-methoxy-3-substituted methyl-3(or 2

1974-10-21

1976-06-08

Rizzo, Nicholas S.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424246, C07D50102

Patent

active

039622312

ABSTRACT:
A process for preparing 7-acylamido-7-methoxy-3-substituted methyl-3(or 2)-cephem-4-carboxylic acid and its S-oxide and its salts, esters and amides which comprises treating 7-acylamido-7-methoxy-3-methyl-3(or 2)-cephem-4-carboxylic acid and its S-oxide or the salts or ester derivatives thereof with a reagent capable of replacing a hydrogen atom of the 3-methyl radical with a halo, hydroxy or lower alkanoyloxy radical. The products are either antibiotics or are useful intermediates in the preparation of antibiotics.

REFERENCES:
patent: 3853860 (1974-12-01), Weir

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