S-alkyl-isothioureido-amino acids and use thereof

Details S-alkyl-isothioureido-amino acids and use thereof S-alkyl-isothioureido-amino acids and use thereof

1993-11-15

1994-11-15

Lee, Mary C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

558 5, A61K 31215, C07C33532

Patent

active

053648811

ABSTRACT:
Inhibitors of nitric oxide formation from arginine useful for treating hypotension, inflammation, stroke and to restore vascular contractile sensitivity to the effects of .alpha..sub.1 -adrenergic agonists are physiologically active compounds including N.sup..delta. -substituted ornithine or N.sup..epsilon. -substituted lysine moieties or monoalkyl carbon-substituted N.sup..delta. -substituted ornithine or N.sup..epsilon. -substituted lysine moieties, having the formula ##STR1## wherein R is (CH.sub.2).sub.y CH.sub.3 or H, R' is CH.sub.2 or C(H)(CH.sub.2).sub.y CH.sub.3, and R" is CH.sub.2 or C(H)(CH.sub.2).sub.y CH.sub.3, with y ranging from 0 to 5, and x is 0 or 1 and wherein none or only one of R, R' and R" provides an alkyl substituent on ornithine or lysine moiety, and wherein Q is alkyl having 1 to 5 carbon atoms, and physiologically acceptable acid addition salts thereof.

REFERENCES:
patent: 5216025 (1993-06-01), Gross et al.
patent: 5281627 (1994-01-01), Griffith
patent: 5296466 (1992-03-01), Kilbourn et al.
Adnot, S., et al, Chem. Abstr. 119:46606f (1992).
Hishikawa, K., Chem. Abstr. 117:5022c (1992).
Griffith, O. W., et al, poster titled "Inhibitions of Nitric Oxide Synthase: Structural Constraints on Binding and Mechanism of Action" presented at the 3rd International Meeting on the Biology of Nitric Oxide, Cologne, Germany, Oct. 1993.
Bodanszky, M., et al, The Practice of Peptide Synthesis, Springer-Verlang, New York, 1984, pp. 48, 49, 153, 154.
Feldman, P. L., Tetrahedron Lett., 32, 875-878, 1991.
Rees, D. D., et al, Br. J. Pharmacol., 96, 418-424 (1989).
Gray, G. A., et al, Br. J. Pharmacol., 103, 1218-1224 (May 1991).
Aisaka, K., et al, Biochem. Biophys. Res. Commun. 163, No. 2, 710-717 (Sep. 15, 1989).
Jolou-Schaeffer, G., et al, Am. J. Physiol. 259, H1038-H1043, Oct. 1990.

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