Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1993-02-11
1994-11-15
Chang, Celia
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514429, 514183, 514212, 514218, 5142222, 5142268, 5142275, 5142288, 514247, 514255, 514256, 514634, 514637, 540450, 540470, 540484, 540544, 540553, 540575, 546231, 544 3, 544 53, 544 59, 544 63, 544 88, 544169, 544224, 544238, 544373, 548567, 548577, 564237, A61K 31445, C07D21128, C07D20706, C07C27910
Patent
active
053648684
ABSTRACT:
Amino-substituted benzoylguanidines, process for their preparation, their use as a medicament and medicament containing them
Benzoylguanidines of the formula I ##STR1## are described in which R(1) or R(2) is an amino group --NR(3)R(4), where R(3) and R(4) are H or (cyclo)alkyl or R(3) is phenyl-(CH.sub.2).sub.p -- where p=0, 1, 2, 3 or 4, or phenyl, or R(3) and R(4) can also together be a methylene chain, and in which the other substituent R(1) or R(2) in each case is H, F, Cl, alkyl, alkoxy, CF.sub.3, C.sub.m F.sub.2m+1 --CH.sub.2 --, benzyl or phenoxy, and their pharmaceutically tolerable salts.
The compounds according to the invention have very good antiarrhythmic properties, as occur, for example, in the case of oxygen deficiency symptoms. The compounds are used as antiarrhythmic pharmaceuticals having a cardioprotective component for infarct prophylaxis and infarct treatment as well as for the treatment of angina pectoris, where they also preventively inhibit or greatly decrease the pathophysiological processes in the formation of ischemically induced damage, in particular in the production of ischemically induced cardiac arrhythmias.
REFERENCES:
patent: 3006913 (1961-10-01), Mull
patent: 3780027 (1973-12-01), Cragoe, Jr. et al.
patent: 3968243 (1976-07-01), Maxwell
patent: 4318915 (1982-03-01), Cohnen
patent: 4602041 (1986-07-01), Newsome
patent: 5006523 (1991-04-01), Atwal
patent: 5091394 (1992-02-01), Englert
patent: 5190976 (1993-03-01), Weber
Caton "Benzamido-Derivatives of Et-2-NH.sub.2 -4-Me-Pyrimidine-5-Carboxylate" J. Chem. Soc. (C) 1269-70 (1969).
Riesz et al "Chemical Composition and Affinity for Macromolecular Compound" Chem. Abs. 62 1763g (1965).
W. Scholz, et al. "Effects of Na.sup.+ /H.sup.+ Exchange Inhibitors in Cardiac Ischemia," J. Mol. Cell Cardiol. 24, 731-740 (1992).
E. Riesz, et al. "Constitution chimique et affinite pour les composes macromoleculaires. I. Recherches sur les derives benzoyles de la quanidine" Bulletin de la Societe chimique de France, 1964, pp. 1517-1524.
Albus Udo
Englert Heinrich
Lang Hans-Jochen
Linz Wolfgang
Mania Dieter
Chang Celia
Hoechst Aktiengesellschaft
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