Camptothecin analogs as potent inhibitors of topoisomerase I

Details Camptothecin analogs as potent inhibitors of topoisomerase I Camptothecin analogs as potent inhibitors of topoisomerase I

1992-12-08

1994-11-15

Goldberg, Jerome D.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514283, A61K 3144

Patent

active

053648587

ABSTRACT:
A method for synthesizing camptothecin and camptothecin analogs using a novel hydroxyl-containing tricyclic intermediate and the camptothecin analogs produced by the process. The camptothecin analogs are effective inhibitors of topoisomerase.I and show antileukemic and anti-tumor activity.

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