Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1990-09-25
1994-11-15
Hill, Jr., Robert J.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
435 694, 4353201, 4352401, 4352402, 536 235, 536 2351, C12N 510, C12N 1518, C12N 1512
Patent
active
053647696
ABSTRACT:
A novel polypeptide, designated neurotrophic factor-4 (NT-4), has been identified by PCR amplification of human genomic DNA. Provided herein is nucleic acid encoding NT-4 useful in diagnostics and in the recombinant preparation of NT-4. NT-4 is used in the treatment of nerve cells and in diagnostic assays.
REFERENCES:
patent: 4699875 (1987-10-01), Appel et al.
patent: 4997929 (1991-03-01), Collins et al.
Ibanez et al. "Structure-Function Studies of Nerve Growth Factor: Functional Importance of Highly Conserved Amino Acid Residues" EMBO 9(5) 1477-1483, May 1990.
Berkemeier et al., Neuron, 7:857-866 (1991).
Wion et al., FEBS, 203:82-86 (1986).
Leibrock et al., Nature, 341: 149-152 (1989).
Tiercy & Shooter, J. Cell Biol., 103(6Pt.1): 2367-2378 (1986).
Korsching & Thoenen, PNAS USA, 80:3513-3516 (1983).
Shelton & Reichadt, PNAS USA, 81: 7951-7955 (1984).
Levi-Montalcini & Hamburger, J. Exp. Zool., 116: 321-361 (1951).
Oppenheim et al., J. Comp. Neurol., 210: 174-189 (1982).
Johnson et al., Trends Neurosc., 9: 33-37 (1986).
Thoenen et al., Rev. Physiol. Biochem. Pharmacol., 109: 145-178.
Barde et al., ENBO J., 1(5): 549-553 (1982).
Barde, Neuron. 2: 1525-1534 (1989).
Hefti, J. Neurosc., 6(8): 2155-2162 (1986).
Lindsay et al., Dev. Biol., 112: 319-328 (1985).
Hohn et al., Nature, 344: 339-341 (1990).
Maisonpierre et al., Science, 247: 1446-1451 (1990).
Coughlin & Collins, Dev. Biol., 110: 392-401 (1985).
Rosenthal et al., Neuron, 4: 767-773 (1990).
Hallbook, et al., Neuron. 6:845-858 (1991).
Allen Marianne Porta
Genentech Inc.
Hill Jr. Robert J.
Johnston Sean A.
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