Process for the preparation of penems

Details Process for the preparation of penems Process for the preparation of penems

1992-09-04

1994-11-15

Marx, Irene

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing compound having a 1-thia-4-aza-bicyclo

435197, 435198, C12P 3700

Patent

active

053647688

ABSTRACT:
An in vitro process for preparing 6((1R)-hydroxyethyl) penem acids by hydrolyzing the carboxylic ester derivative thereof using an enzyme capable of selectively hydrolyzing the ester group at the 3-position of the carboxylic acid ester using an esterase, acylase or lipase enzyme, wherein the enzymatic hydrolysis is effected at a pH in the range of from 5 to 8 and at a temperature in the range of 20.degree. C. to 40.degree. C.

REFERENCES:
patent: 5215891 (1992-03-01), Altamura

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