Purinyl tetrahydrofurans

Details Purinyl tetrahydrofurans Purinyl tetrahydrofurans

Filed on

1990-05-01

Date issued

1991-10-22

Examiner

Rivers, Diana G.

Patent Class

Organic compounds -- part of the class 532-570 series

SubClass

Organic compounds

SubSubClass

Chalcogen bonded directly to ring carbon of the purine ring...

Other Related Categories

544244, 544265, 544277, 544313, 544314, 544317, 544243, 549476, A61K 3152, C07D47318, C07D47330, C07D47334

Type

Patent

Status

active

Patent number

050596900

Description

ABSTRACT:
Antiviral activity is exhibited by compounds having the formula ##STR1## and pharmaceutically acceptable salts thereof wherein R.sub.1 is a purine or pyrimidine base or an analog thereof and R.sub.2 and R.sub.3 are independently hydrogen, --PO.sub.3 H.sub.2 or ##STR2## wherein X.sub.7 is hydrogen, alkyl, substituted alkyl or aryl.

REFERENCES:
patent: 4788181 (1988-11-01), Driscoll et al.
patent: 4855466 (1989-08-01), Zahler et al.
patent: 4918075 (1990-04-01), Zahler et al.
Ueda et al., "Chemical Conversion of Nucleosides . . . ", Nucleic Acids Research, Symposium #9, 1981, pp. 91-94.
Shuto et al., "Chemical Conversion of Uridine to . . . ", Nucleosides & Nucleotides, 1(3), 263-273 (1982).
Rosenthal et al., "Branched-Chain Sugar Nucleosides . . . ", Canadian Jour. of Chem., vol. 47, pp. 4477-4481 (1969).
Acton et al., "Improved Antitumor Effects . . . ", Jour. Med. Chem., vol. 22, pp. 518-525 (1979).
Bamford et al., "Synthesis and Antiviral Activity . . . ", Jour. Med. Chem., vol. 33, pp. 2494-2501 (1990).
Pudlo et al., "A New Novel Approach Towards . . . ", Tetrahedron Letters, vol. 31, pp. 3101-3104 (1990).
Slusarchyk et al., U.S. Serial No. 322,375 filed 3/13/89.
DeClercq et al., "Targets for the Design of Antiviral Agents", 1983, pp. 203-230.
Herdewijn et al., "Synthesis and Antiviral Activity . . . ", J. Med. Chem., 1985, vol. 28, pp. 550-555.
Takano et al., "Enantio-Controlled Route . . . ", J. Chem. Soc. Chem. Commun., 1988, pp. 189-191.

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