Substituted 2-aminomethyl-6-iodophenols

Details Substituted 2-aminomethyl-6-iodophenols Substituted 2-aminomethyl-6-iodophenols

1976-09-20

1977-06-14

Hines, Robert V.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Recombinant or stably-transformed bacterium encoding one or...

260433, 26050117, 26050119, 260553A, 260558R, 260559S, 260562A, 260562B, 2605709, 260612D, 260623R, 424330, A01N 920, A01N 924, C07C 8728

Patent

active

040298167

ABSTRACT:
Certain substituted 2-aminomethyl-6-iodophenols and their pharmaceutically acceptable acid addition salts wherein the phenyl nucleus may be further substituted with 1 to 3 nuclear substituents are useful as antihypertensive, diuretic and saluretic agents. These products may be prepared by either iodinating a 2-aminomethyl-3,4,5-substituted phenol or hydrolyzing an appropriately substituted N-(2-hydroxy-3-iodo-4,5,6-substituted benzyl)carboxamide under either acidic or basic conditions.

REFERENCES:
patent: 2220835 (1950-11-01), Bruson et al.
patent: 3082113 (1963-03-01), Hemwall
patent: 3781359 (1973-12-01), Randall et al.
patent: 3794734 (1974-02-01), Cragoe, Jr. et al.
patent: 3864401 (1975-02-01), Cragoe, Jr. et al.
patent: 3928624 (1975-12-01), Cragoe, Jr. et al.
Miyoshi, "Jour. Chem. Soc. Ind. Japan," vol. 49, pp. 64-67 (1946).
Miyoshi, "Chemical Abstracts," vol. 42, p. 6154 (1948).
Arct et al., "Chemical Abstracts," vol. 61, pp. 3000-3081 (1964).

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