Process for the preparation of 4-hydroxyquinolines

Details Process for the preparation of 4-hydroxyquinolines Process for the preparation of 4-hydroxyquinolines

1983-06-16

1985-04-02

Berch, Mark L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D21522

Patent

active

045089027

ABSTRACT:
Process for the preparation of a 4-hydroxyquinoline of the formula: ##STR1## in which R represents a hydrogen atom or one, two or three substituents, which may be the same or different, selected from halogen atoms, alkyl radicals containing 1 to 4 carbon atoms, alkoxy radicals containing 1 to 4 carbon atoms, and the trifluoromethyl radical, the substituent(s) being in the 2-, 3-, 5-, 6-, 7- or 8-position, which comprises oxidizing a 1,2,3,4-tetrahydroquinolin-4-one of the general formula: ##STR2## in which R is as hereinbefore defined, in a basic medium, under pressure, by means of excess oxygen or air at a temperature between 80.degree. and 150.degree. C.
The 4-hydroxyquinoline products are useful for the preparation of therapeutically useful substances.

REFERENCES:
patent: 2558211 (1951-06-01), Elderfield
patent: 4412076 (1983-10-01), Baudouin et al.
Johnson et al., J.A.C.S., 74, 4513(1952).

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