Benzoic acid amides for mycobacterium infections

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...

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A61K 3144

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active

040062392

ABSTRACT:
Benzoic acid amides characterized by the presence of a hydroxy or amino substituent in the phenyl ring, or an alkylated or acylated derivative thereof and by a heterocyclic group connected to the amide nitrogen atom through a hydrocarbon chain are antibacterial agents and in particular anti-tuberculosis agents. The compounds, of which N-[pyridyl-(2)-methyl]-2-hydroxybenzoic acid amide is a typical embodiment, are prepared by the reaction of an appropriately substituted benzoic acid, or derivative thereof, with an appropriate amine.

REFERENCES:
patent: 2870156 (1959-01-01), Perron et al.
patent: 3367940 (1968-02-01), Hotten
patent: 3455940 (1969-07-01), Stecker
patent: 3676447 (1972-07-01), Skinner et al.

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