Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1982-09-30
1987-02-24
Brust, Joseph Paul
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514357, 546329, 546330, 546333, 546339, 546340, 546342, 546343, 546348, 546346, A61K 3144
Patent
active
046457712
ABSTRACT:
The disclosure concerns novel 1-benzyl-1,2,3,6-tetrahydropyridine derivatives of the formula: ##STR1## wherein R.sup.1 is hydrogen or a (1-4C)-alkyl radical, and benzene ring A bears one or two substituents selected from combinations of halogeno, (1-4C)-alkyl, (1-4C)-alkoxy, hydroxy, nitro, cyano, carboxamido, carboxyl, [(1-4C)-alkoxy]carbonyl, hydroxymethylene, amino, (1-4C)-alkanoylamino, (1-4C)-alkylsulphonamido, [(1-4C)-alkoxy]carbonyloxy, (1-4C)-alkanoyloxy and optionally substituted benzoyloxy radicals, and their pharmaceutically acceptable salts; pharmaceutical compositions thereof; analogy processes for their manufacture; and methods of medical treatment employing such derivatives.
The compounds of formula I are inhibitors of the aggregation of blood platelets and are of application in the treatment or prophylaxis of thrombosis or occlusive vascular disease. Representative compounds possessing particularly good blood platelet aggregation inhibitory properties are 1-(3,4-dichloro-, 4-chloro-3-hydroxy-, and 4-hydroxy-benzyl)-1,2,3,6-tetrahydropyridine, preferably as their hydrochloride salts.
REFERENCES:
patent: 2609270 (1952-09-01), Couper
patent: 2967182 (1961-01-01), Pohland
patent: 3125488 (1964-03-01), Biel
patent: 3284457 (1966-11-01), Beschke et al.
patent: 3632767 (1972-01-01), Gray et al.
patent: 3758483 (1973-09-01), Edenhofer
patent: 4001414 (1977-01-01), Jarque et al.
patent: 4028371 (1977-06-01), Jarque et al.
patent: 4225602 (1980-09-01), Johnson et al.
patent: 4267183 (1981-05-01), Johnson et al.
Petrow, et al., J. Pharm. Pharmacal., 1962, 14, pp. 306-314.
Podesta, et al., Eur. J. Med. Chem.-Chimica Therapeutica, 1974, 9, pp. 487-490.
Oediger, et al., Liebigs Ann. Chem., 784 (1972) pp. 21-27.
Brust Joseph Paul
Imperial Chemical Industries plc
LandOfFree
Tetrahydropyridine derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Tetrahydropyridine derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Tetrahydropyridine derivatives will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-109151