Aryloxymethylpyrrolidinols and piperidinols having antidepressan

Details Aryloxymethylpyrrolidinols and piperidinols having antidepressan Aryloxymethylpyrrolidinols and piperidinols having antidepressan

1984-02-03

1985-04-02

Milestone, Norma S.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514319, 514424, 546206, 546216, 546222, 548556, C07D21148, C07D20712, A61K 3140, A61K 31445

Patent

active

045087245

ABSTRACT:
Novel aryloxymethylpyrrolidinols and piperidinols are provided of the formula: ##STR1## wherein R.sup.1 is hydrogen, loweralkyl and phenylloweralkyl; R.sup.2 is hydrogen, loweralkyl and acyl; R.sup.3 is phenyl, naphthyl, 4-indanyl and 5-indanyl; m is 2 or 3 and n is 1 or 2; and the pharmaceutically acceptable salts thereof, having antiarrhythmic, antidepressant and antihypertensive activity.

REFERENCES:
Chemical Abstracts, vol. 73, (1970), 66442j.
Chemical Abstracts, vol. 79, (1973), 126228e.
Shiro Morosawa, Bull. Chem. Soc. Japan, (1960), vol. 33(5), pp. 575-578.

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