Pyridazin-3-one derivatives

Details Pyridazin-3-one derivatives Pyridazin-3-one derivatives

1982-11-03

1985-04-02

Rizzo, Nicholas S.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

544238, 544239, C07D23706, A61K 3150

Patent

active

045087210

ABSTRACT:
Heterocyclic compounds of the formula: ##STR1## wherein the dotted line in the pyridazine nucleus indicates that a double bond is optional in this position, and wherein Py is a 2-, 3- or 4- pyridinyl group which is unsubstituted, or which bears one or two substituents selected from halogen, cyano, hydroxymethyl, carboxy, carbamoyl and alkyl, alkoxy, alkoxycarbonyl, alkylcarbamoyl and dialkylcarbamoyl wherein each alkyl or alkoxy has up to 4 carbon atoms, or which bears an oxygen substituent, either as an N-oxide or as an oxo substituent on the 2- or 4- carbon atom (that is, such as to form a pyridone); and acid-addition salts thereof; processes for their manufacture and pharmaceutical compositions containing them. The compounds possess cardiotonic and/or antihypertensive properties.

REFERENCES:
patent: 4298609 (1981-11-01), Lesher et al.
patent: 4304777 (1981-12-01), Lesher et al.
patent: 4346221 (1982-08-01), Lesher et al.

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