Antagonism of central nervous system drugs by the administration

Details Antagonism of central nervous system drugs by the administration Antagonism of central nervous system drugs by the administration

1982-04-13

1985-04-02

Friedman, Stanley J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514282, 514321, 514352, A61K 31485, A61K 31495, A61K 31515, A61K 31335, A61K 31415, A61K 31445, A61K 31475, A61K 3144, A61K 3154, A61K 31045, A61K 31195

Patent

active

045087156

ABSTRACT:
The use of 4-aminopyridine and congeners or derivatives thereof to antagonize drugs which act at or upon central nervous system receptors, especially dopamine receptors, such as butyrophenones and congeners or derivatives thereof is disclosed. 4-Aminopyridine is used above or in combination with other drugs such as naloxone hydrochloride or yohimbine hydrochloride. The use of 4-Aminopyridine overcomes the problems of drug overdoses of drugs which act at or upon central nervous system receptors, especially dopamine receptors by reversing the effects of toxic amounts or toxic dosages.

REFERENCES:
Chem. 91 (1979)-83512w.
Chem. 94 (1981), 24779c & 132198w.
Chem. Abst. (1981)-54992(95).
Chem. Abst. 96 (1982), 173679p.
Chem. Abst. 97 (1982), 33306k.

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