Aromatic heterocyclic derivatives and their thereapeutic and cos

Details Aromatic heterocyclic derivatives and their thereapeutic and cos Aromatic heterocyclic derivatives and their thereapeutic and cos

1989-11-02

1991-10-22

Richter, Johann

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514432, 514456, 514469, 549 23, 549 57, 549 58, 549407, 549467, 549468, A61K 3138, C07D33506

Patent

active

050596217

ABSTRACT:
An aromatic heterocyclic compound has the formula ##STR1## wherein R.sub.1 represents (i) --CH.sub.3, (ii) --CH.sub.2 OH or (iii) ##STR2## wherein R.sub.3 represents hydrogen, --OR.sub.4 wherein R.sub.4 represents hydrogen, alkyl having 1-20 carbon atoms, mono- or polyhydroxyalkyl or R.sub.3 represents ##STR3## wherein r'and r" represent hydrogen or lower alkyl, R.sub.2 represents hydrogen or --CH.sub.3 and Ar represents ##STR4## wherein Z is O or S, ##STR5## wherein R.sub.5 is lower alkyl or ##STR6## wherein R.sub.6 is hydrogen or alkyl having 1-10 carbon atoms and R.sub.7 represents alkyl having 4-12 carbon atoms or cycloalkyl, Y is CH and X represents oxygen or sulfur, with the proviso that (i) when Y is CH and X is oxygen or sulfur Ar is other than C wherein R.sub.5 is CH.sub.3 and (ii) when Y is CH and X represents sulfur Ar is other than A.
The compound is useful in the treatment of dermatologic ailments linked to a keratinization disorder.

REFERENCES:
Shroat et al. Chem. Abstracts, vol. 106; No. 9; 67099q (1987).
Shroat et al. Chem. Abstracts, vol. 107; No. 5; 39607f (1987).
Chem. Abstracts, vol. 106, No. 5; 35051c (1987).
Shrout et al. Chem. Abstracts, vol. 105; No. 21, 190908j (1986).

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