Preparation of substituted piperidines

Details Preparation of substituted piperidines Preparation of substituted piperidines

1985-11-04

1987-04-07

Ford, John M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546112, 546184, 546192, 546203, 546205, C07D21112, C07D21114, C07D21702, C07D21704

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046562826

ABSTRACT:
Piperidines substituted in the 3- and/or 4-position are prepared by reacting a glutardialdehyde substituted in the 2- and/or 3-position with ammonia or a primary amine and hydrogen at elevated temperature and under superatmospheric pressure in the presence of a hydrogenation catalyst.

REFERENCES:
Borch et al., "J. American Chem. Soc.", vol. 93, pp. 2897-2904 (1971).
Kirk-Othmer "Encyclopedia of Chemical Technology", vol. 7, pp. 692, 693 and 697 (1951).
Gilman's Organic Chemistry, vol. 1, 2nd Edition, Chapter 9, pp. 779-833 (1943), fifth printing Jun. 1947.
Houben-Weyl, vol. 11/1, (1957), pp. 693-695, 698,278, 593/594, 117 and 225.
Org. Synth. Coll. vol. IV (1963), pp. 795 and 816.
Nielsen, J. Heterocycl. Chem. 12 (1975) pp. 1, 161.
Y. Watanabe et al., Bull. Chem. Soc. Jap. 49 (1976) 8, 2302.
C. F. Lane, Synthesis (1975), 135-142.

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