Cyclic prodrugs of antiinflammatory oxicams

Details Cyclic prodrugs of antiinflammatory oxicams Cyclic prodrugs of antiinflammatory oxicams

1984-06-21

1987-04-07

Ford, John M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D41314, C07D41714

Patent

active

046562656

ABSTRACT:
Compounds of the formula ##STR1## or a pharmaceutically acceptable acid addition salt thereof wherein R is 2-pyridyl, 6-chloro-2-pyridyl, 6-methyl-2-pyridyl or 5-methylisoxazol-3-yl; useful as prodrug forms of the corresponding known oxicam antiinflammatory and analgesic agents, piroxicam, the corresponding 6-chloro-2-pyridyl and 6-methyl-2-pyridylcarboxamides, isoxicam and tenoxicam; methods for their use, pharmaceutical compositions containing them and a process for their preparation.

REFERENCES:
patent: 3492298 (1970-01-01), Rasmussen
patent: 3591584 (1971-07-01), Lombardino
patent: 3787324 (1974-01-01), Zinnes et al.
patent: 3822258 (1974-07-01), Zinnes et al.
patent: 3923801 (1975-12-01), Rasmussen
patent: 4180662 (1979-12-01), Pfister et al.
patent: 4309427 (1982-01-01), Lombardino
patent: 4376768 (1983-03-01), Ozaki et al.
patent: 4563452 (1986-01-01), Soler
Zinnes et al., J. Med. Chem., 16, 44-48 (1973).
Del Favero, "Side Effects of Drugs Annual 7", Dukes and Elis, Eds. Excerpta Medica, Amsterdam, 1983, pp. 104-105.

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