Treatment of mammary cancer

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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514648, A61K 3140, A61K 31135

Patent

active

046561870

ABSTRACT:
Mammary cancers are inhibited by administration of a combination of two drugs. The first compound is 6-hydroxy-2-(4-hydroxyphenyl)-3-[4-(2-pyrrolidinoethoxy)benzoyl]benzo[b]th iophene, and the second compound is tamoxifen.

REFERENCES:
patent: 2914563 (1959-11-01), Allen et al.
patent: 3272841 (1966-09-01), DeWald
patent: 3274213 (1966-09-01), Lednicer
patent: 3875242 (1975-04-01), Lednicer
patent: 4133814 (1979-01-01), Jones et al.
patent: 4230862 (1980-10-01), Suarez et al.
Faye et al., Biochem. And Biophys. Res. Comm. 93, 1225-31 (1980).
Sutherland et al., Nature 288, 273-75 (1980).
U.S. Application Ser. No. 246,335, Jones, Eli Lilly and Co. filed Apr. 3, 1981.

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