Peptide, and production and use thereof

Details Peptide, and production and use thereof Peptide, and production and use thereof

1985-02-27

1987-04-07

Phillips, Delbert R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530324, 530344, A61K 3702, C07K 710, C07K 324

Patent

active

046561587

ABSTRACT:
There are disclosed a new peptide .beta.-hANP of the following structure: ##STR1## and acid addition salt thereof; a diuretic composition and a hypotensor composition containing a .beta.-hANP or an acid addition salt thereof; and processes for the production thereof.

REFERENCES:
Jamieson, J. D. and Palade, G. E., "Specific Granules in Atrial Muscle Cells", The Journal of Cell Biology, vol. 23, (1964), pp. 151-172.
de Bold, A. J. et al, "A Rapid and Potent Natriuretic Response to Intravenous Injection of Atrial Myocardial Extract in Rats", Life Sciences, vol. 28, (1981), pp. 89-94.
Keeler, R., "Atrial Natrieuretic Factor has a Direct, Prosteglan-Independent Action on Kidneys", Can. J. Physiol. Pharmacol, vol. 60, (1982), pp. 1078-1082.
Currie, M. G. et al, "Bioactive Cardiac Substances: Potent Vasorelaxant Activity in Mammalian Atria", Science, vol. 221, (1983), pp. 71-73.
Flynn, T. G. et al, "The Amino Acid Sequence of an Atrial Peptide with Potent Diuretic and Natriuretic Properties", Biochemical and Biophysical Research . . . .
Kanagawa, K. and Matsuo, H., "Purification and Complete Amino Acid Sequence of .alpha.-Human Atrial Natriuretic Polypeptide, (.alpha.-haNP)" Biochemical and Biophysical . . . .

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