Process for the preparation of 4-amino-chloroquinolines

Details Process for the preparation of 4-amino-chloroquinolines Process for the preparation of 4-amino-chloroquinolines

1982-01-15

1983-12-20

Rivers, Diana G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546159, 546160, 546161, 546162, C07D21542, C07D21544, C07D21546

Patent

active

044219202

ABSTRACT:
4-Amino-chloroquinolines of the formula: ##STR1## in which R.sub.1 represents a hydrogen atom or an alkyl radical (1 to 5 carbon atoms), and R.sub.2 represents an alkyl radical (1 to 5 carbon atoms) optionally substituted by a dialkylamino group, or a phenyl radical optionally substituted by one or more carboxy and hydroxy radicals and alkyl radicals (1 to 4 carbon atoms) optionally substituted by a dialkylamino group, are prepared by the condensation of an amine of the formula: ##STR2## with a chloro-1,2,3,4-tetrahydroquinolin-4-one of the formula: ##STR3## with aromatization of the tetrahydroquinoline, the reaction being carried out in the presence of a ruthenium based catalyst on a support.
The 4-amino-chloroquinoline products are useful as pharmaceuticals.

REFERENCES:
patent: 2653940 (1953-09-01), Johnson
Chem Systems, Inc., Chemical Abstracts, vol. 81, 3574y, (1974).

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