Antiviral antibiotic complex

Details Antiviral antibiotic complex Antiviral antibiotic complex

1986-05-01

1989-02-07

Shippen, Michael L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Radical -xh acid, or anhydride, acid halide or salt thereof...

435129, 562561, C07C10350, A61K 31195

Patent

active

048032247

ABSTRACT:
There is disclosed an antibiotic complex designated as BU-2231 V which is produced by fermentation of a BU-2231-producing strain of Streptoalloteichus hindustanus, ATCC 31158. Complex BU-2231 V is recovered and purified from the fermentation broth by use of ion exchange chromatography techniques. Structural analysis shows that the complex is a mixture of components which are .gamma.-homopolymers of D-.alpha.,.gamma.-diaminobutyric acid having an average molecular weight of from about 5,100 to about 5,200. BU-2231 V has been found to be effective to inhibit growth of various Gram-positive and Gram-negative bacteria and of the herpes simplex virus.

REFERENCES:
Shima, Agric. Biol. Chem., 45, pp. 2503-2508 (1981).

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