Hypoglycemic 2',3',10'-tetrahydro-10'-hydroxy-10'-substituted-sp

Details Hypoglycemic 2',3',10'-tetrahydro-10'-hydroxy-10'-substituted-sp Hypoglycemic 2',3',10'-tetrahydro-10'-hydroxy-10'-substituted-sp

1987-03-09

1989-02-07

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

544231, 546201, 548410, 548485, C07D48704, A61K 31505

Patent

active

048032077

ABSTRACT:
Pyrimidoindoles of formula (I) ##STR1## and their pharmaceutically acceptable acid addition salts, wherein R represents lower alkyl a mono- or bicyclic aryl radical or a group of mormula R.sup.3 O--B--[where R.sup.3 O is (lower)alkoxy,aryl(lower)alkoxy or hydroxy and B is a lower alkylene chain optionally containing one double or triple bond], R.sup.1 and R.sup.2 which may be the same or different each represent hydrogen, hydroxyl, lower alkyl, lower alkoxy, halo(lower)alkyl, halogen, amino or mono- or di(lower) alkylamino and A, together with the carbon atom to which it is attached, represents 5, 6 or 7 membered saturated carbocyclic or heterocyclic ring, are useful as hypoglyceamics.

REFERENCES:
patent: 2984666 (1961-05-01), Bortnick et al.
patent: 3634426 (1972-01-01), Eberle
patent: 3891644 (1975-06-01), White

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