Chemistry: molecular biology and microbiology – Spore forming or isolating process
Patent
1986-06-04
1989-02-07
Rosen, Sam
Chemistry: molecular biology and microbiology
Spore forming or isolating process
435 1, 435178, 264 4, 935 54, 424422, 424424, 424425, C12N 500
Patent
active
048031682
ABSTRACT:
Disclosed is a process for damage-free encapsulation of a variety of core materials including viable cells. The core material is suspended in an aqueous solution of a polymeric material containing cationic groups such as an aminated glucopolysaccharide, e.g. chitosan. A temporary matrix is formed by gelling droplets of the suspension with a divalent or multivalent anion. The temporary matrix is permanently cross-linked with a polymeric material containing plural anionic groups, e.g., polyaspartic or polyglutamic acid, to form a semipermeable membrane. The interior of the microcapsule may be resolublized by subjecting the capsule to a solution of low molecular weight cations. The process produces microcapsules which are not sticky, do not clump and allow viable cell growth and proliferation.
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Damon Biotech, Inc.
Rosen Sam
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