Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Enzymatic production of a protein or polypeptide
Patent
1987-04-22
1989-02-07
Martinell, James
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Enzymatic production of a protein or polypeptide
435 70, 435 71, 4351721, 4351723, 435255, 435256, 435320, 536 27, 935 12, 935 37, 935 61, 935 69, C12P 2100, C12P 2102, C12P 2104, C12N 1500
Patent
active
048031640
ABSTRACT:
Hepatitis surface antigen is synthesized in recombinant yeast hosts transformed with vectors encoding hepatitis surface antigen, preferably under the control of the yeast PGK promoter and preferably in the absence of DNA encoding the surface antigen precursor. Hepatitis surface antigen is assembled by yeast into antigenic 22 nm particles even though hepatitis surface antigen bacterial transformants were not known to be capable of assembling the surface antigen into 22 nm particles.
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Hitzeman Ronald A.
Levinson Arthur D.
Yansura Daniel G.
Genentech Inc.
Martinell James
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