Surgery – Controlled release therapeutic device or system – Osmotic or diffusion pumped device or system
Patent
1985-09-26
1987-04-07
Lieberman, Allan M.
Surgery
Controlled release therapeutic device or system
Osmotic or diffusion pumped device or system
428156, 604897, A61F 1302, A61J 100
Patent
active
046557679
ABSTRACT:
This invention relates to an improved transdermal drug delivery device for the controlled transdermal delivery of amino-functional drugs. The improvement resides in providing the device with a silicone pressure-sensitive adhesive layer which has been chemically treated to reduce the silicon-bonded hydroxyl content of the pressure-sensitive adhesive composition to render the adhesive layer resistant to loss of tack and preserve the instant adherence of the device to the skin of a wearer during storage and while the device is being worn. Preferably, the composition used comprises a silicon-bonded hydroxyl radical containing resinous copolymer of R.sub.3 SiO.sub.1/2 units and SiO.sub.4/2 units and a polydiorganosiloxane which have been chemically treated with R.sub.3 SiO.sub.1/2 units where R is preferably a hydrocarbon radical such as a methyl group to reduce the silicon-bonded hydroxyl content of the adhesive and thereby its sensitivity to amino-functional drugs.
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One page memo "To: All Adhesives Customers" From: S. Michael John, Silicone Products Division, General Electric Company, Waterford, N.Y. dated Aug. 1983 containing the following data sheets (2 pages each): CDS-4131, SRC 18, PSA 518, PSA 529, PSA 590, PSA 595, PSA 596, PSA 6573, PSA 6574, CDS-4138.
Metevia Virgil L.
Woodard John T.
Dow Corning Corporation
Lieberman Allan M.
Rakoczy Richard E.
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