Reagent for making Technetium-99m labelled tin colloid for body

Details Reagent for making Technetium-99m labelled tin colloid for body Reagent for making Technetium-99m labelled tin colloid for body

1984-04-13

1987-02-24

Nucker, Christine M.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

424 9, 422 61, A61K 4900, A61K 4300

Patent

active

046456597

ABSTRACT:
A packaged reagent for making Technetium-99m labelled tin colloids comprises 0.75 to 750 .mu.g stannous tin, 50 to 7000 .mu.g sodium, potassium or ammonium ion, 40 to 5000 .mu.g fluoride ion, 50 to 10,000 .mu.g of a non-toxic non-ionic surface-active agent based on poly (alkylene oxide)glycol and a container aseptically enclosing said reagent. The presence of the surface-active agent, preferably one of the Pluronic types, results in smaller sized particles being produced on addition of pertechnetate to the reagent. This results in a higher liver/spleen biodistribution ratio.

REFERENCES:
patent: 3992513 (1976-11-01), Petkau et al.
patent: 4054645 (1977-10-01), Hill et al.
patent: 4066742 (1978-01-01), Garrett
patent: 4087516 (1978-05-01), Laidler et al.
patent: 4094965 (1978-06-01), Layne et al.
patent: 4107283 (1978-08-01), Pratt et al.
patent: 4329332 (1982-05-01), Couvreur et al.
patent: 4337240 (1982-06-01), Saklad
patent: 4489055 (1984-12-01), Couvreur et al.

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