Prodrug esters of phenolic 2-piperidino-1-alkanols

Details Prodrug esters of phenolic 2-piperidino-1-alkanols Prodrug esters of phenolic 2-piperidino-1-alkanols

1993-09-16

1995-10-03

Rotman, Alan L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546133, 546217, 544124, A61K 3144, C07D45302

Patent

active

054552508

ABSTRACT:
##STR1## 2-(8-Azabicyclo[3.2.1]oct-8-yl)alkanols of formula (I), wherein Q is S or CH.dbd.CH; X is H, OH or another aromatic substituent; R is hydrogen, alkyl, alkenyl or alkynyl; Y and Y.sup.1 are taken together and are arylmethylene or aralkylmethylene (or corresponding epoxy derivative) or Y and Y.sup.1 are taken separately and Y is hydrogen or OH, and Y.sup.1 is aryl, aralkyl, arylthiol or aryloxy; and structurally related 2-(piperidino)alkanols; pharmaceutical compositions thereof; methods of treating CN disorders therewith; and intermediates useful in the preparation of said compounds.

REFERENCES:
patent: 3294804 (1966-12-01), Carabateas
patent: 3509164 (1970-04-01), Carron et al.
patent: 4393069 (1983-07-01), Langbein et al.
patent: 5185343 (1993-02-01), Chenard
Bundagard et al., J. Med. Chem., 32, 2503-2507 (1989).

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